Sorcery
085/275 Common
Put three -1/-1 counters divided as you choose among one, two, or three target creatures.
While there are no +1/+1 counters anywhere in this set, there are several cards that create -1/-1 counters! They are an effective way to counteract the temporary buffs from Inspiration tokens, which otherwise allow creatures to soak up damage from more traditional removal spells.
Acid Spray is most effective when decimating wide boards of tiny creatures! But it can also stack all those counters on a single target in a pinch.